We previously examined the association between the exposure of surgery and anaesthesia for appendicitis and the subsequent development of Alzheimer’s disease and related dementias (ADRD).1,2 We chose to focus on appendicectomy because appendicitis appears to occur fairly randomly (acting as a natural experiment), and its sequelae are generally not long term, unlike other procedures possibly needed as a result of underlying illnesses that may affect long-term outcomes. Literature has suggested that there are common pathways of neurodegeneration in Parkinson’s disease (PD) and ADRD.3–5 We used the same cohort of patients who received an appendicectomy for appendicitis with similarly matched patients who did not have an appendicectomy, to investigate an association between exposure to surgery and anaesthesia and PD.
