Entrepreneurship and innovation in Africa-pivotal for the continent’s economic progress-present a contrast to Europe and North America with unique challenges and opportunities facing African startups and micro, small, and medium enterprises. This chapter offers a comprehensive examination of these differences and distinctive features of African startup and innovation ecosystems, highlighting insights from extant research and opportunities for empirical exploration and theoretical elaboration. It explores the relevance of these African experiences to similar emerging and developing economies and emphasizes the need for research that specifically addresses these unique dynamics, particularly in areas where existing theories and insights may not fully apply.