Health care data creates unparalleled opportunities to save lives, improve health, strengthen the health care workforce, reduce costs, and increase efficiency. But it also presents a unique set of challenges ranging from privacy to data consistency. In this course, we begin by surveying the health care data landscape and then turn to how to use this rich data to better manage care and organizations. We will refine the art of asking good questions and gain first-hand experience applying analytics to answer them. We will also examine innovative businesses focused on health care data and analytics. At the end of this course, students will: (1) Understand the topography of the health care data landscape, (2) Have the skills necessary to be thoughtful consumers of evidence on health care, (3) Be able to use data and analytics to improve care and health care management, and (4) Anticipate business opportunities in health care data and analytics.